The Significance of Naltrexone in Mental Health Treatment: Insights from a Compounding Pharmacy

Humber Bay Compounding Pharmacy, situated in Toronto, Ontario, is committed to delivering tailored medication solutions to address the distinct requirements of individual patients. Among the customized medications frequently compounded by our pharmacy, Naltrexone, particularly in low doses (LDN), stands out. Originally prescribed for substance use disorders, Naltrexone is now demonstrating potential efficacy in the realm of mental health care​1​​2​.
LDN, comprising doses approximately 10% or less of the typical opioid addiction treatment dosage (usually up to 5mg), exhibits peculiar characteristics, including analgesic and anti-inflammatory effects. These dosages are compounded within our pharmacy and necessitate a prescription. Research has indicated that LDN can be advantageous for individuals with conditions characterized by immune system dysfunction, including specific mental health disorders​2​.
Studies have revealed that LDN may alleviate mood episodes in individuals grappling with bipolar disorder. This positive impact likely arises from LDN's capacity to modulate endorphin levels, which can influence both manic and depressive episodes​1​.
A study conducted in 2006 involving 34 individuals diagnosed with both bipolar disorder and substance use disorder reported substantial improvements in depression and mania symptoms after 16 weeks of Naltrexone treatment. Moreover, Naltrexone did not appear to induce any major adverse effects​1​.
Furthermore, individuals who have taken LDN to manage chronic illness have reported amelioration of co-occurring mental health concerns, such as low or depressed mood, fatigue, sleep disturbances, and impaired daily functioning. These accounts align with a self-controlled cohort study conducted in 2021, which discovered a 65% reduced rate of bipolar disorder diagnosis among participants treated with Naltrexone for alcohol or opioid use disorder​1​.
Moreover, LDN shows potential benefits in the treatment of major depression. A small-scale study conducted in 2017 demonstrated that participants experiencing a recurrence of depression symptoms noticed enhanced symptom relief when 1mg of Naltrexone was added to their medication regimen for a duration of 3 weeks​1​.
At Humber Bay Compounding Pharmacy, we expertly compound Naltrexone in various forms, including tablets, sublingual tablets, oral sublingual drops, oral suspensions, veggie capsules, topical creams, and ultra-low dose Naltrexone (ULDN). We ensure the efficacy and safety of the medication by compounding LDN as an immediate-release capsule or tablet, devoid of specific fillers and binders​2​.
It is imperative to acknowledge that while Naltrexone exhibits promising outcomes in the treatment of specific mental health conditions, its usage should only occur under the supervision of a healthcare professional. Always consult your healthcare provider before initiating any new medication.
For more information, please visit our pharmacy's website at https://www.humberbaypharmacy.com/ or explore our compounding page at https://www.humberbaypharmacy.com/compounding.html.
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